Testing Status of 2,4-Dichlorophenoxyacetic acid 10451-Y

 

CASRN: 94-75-7

Formula: C8-H6-Cl2-O3

Synonyms/Common Names

  • 2,4-D

Known Uses

Pesticide, herbicide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0704)  Completed 
    • Citation: Griffin RJ, Godfrey VB, Kim YC, Burka LT. Sex-dependent differences in the disposition of 2,4-dichlorophenoxyacetic acid in Sprague-Dawley rats, B6C3F1 mice, and Syrian hamsters. Drug Metab Dispos. 1997 Sep;25(9):1065-71.Pubmed Abstract
    • Male and Female Rats: Sprague Dawley; Male and Female Mice: B6C3F1; Male and Female Hamsters: Syrian Golden
  • Toxicokinetic Study (Gavage; Intravenous)  (S0546)  Completed 
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden; Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
    • Dose: PRELM MICE IV: 5.2 MG/KG PO: 5.2, 156.3 MG/KG FEED: 31, 1875 PPM; PRELM RAT IV: 3.56 MG/KG PO: 3.56, 53.6 MG/KG FEED: 83, 2500 PPM; PRELM HAMSTER IV: 8 MG/KG PO: 8, 80 MG/KG FEED: 100, 1000 PPM. SA MICE IV: 1 MG/KG, PO: 1, 2, 5.2 MG/KG; SA RAT IV: 2 MG/KG PO: 1.5, 3.56, 7 MG/KG; SA HAMSTER IV: 8 MG/KG PO: 2, 8, 40 MG/KG..
  • Toxicokinetic Study (Dosed-Feed)  (S0581)  Completed 
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
    • Dose: 14D: HAMSTER 12, 100, 500, 1000 OR 5000 PPM; 90D: RAT 17, 83, 250, 750, 1250 OR 2500 PPM; MICE 12, 28, 83, 250, 700 OR 1680 PPM; HAMSTERS 12, 100, 500, 1000, 5000 ppm.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (079515)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (846375)  Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (541375)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
    •  Negative 
  • Salmonella  (843375)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
    •  Negative 

Organ Systems Toxicity

  • Neurotoxicology Assessment (Gavage)  (NTA94009)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male Rats: F344/N