Testing Status of 1,2,3-Benzotriazole 10453-G

 

CASRN: 95-14-7

Formula: C6-H5-N3

Synonyms/Common Names

  • 1H-Benzotriazole

Known Uses

Photographic restrainer; chemical intermediate; copper corrosion inhibitor; intermediate for dyes, pharmaceuticals, in de-icing fluids for aircraft (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03521)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03521)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 300, 30000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03521)  Report Complete 
    • TR-088 (NIH Number: 78-1338)  (Peer Review Approval 04/26/1978A )
      Bioassay of 1H-Benzotriazole for Possible Carcinogenicity (CASRN 95-14-7)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Equivocal 
      • Male Mice Negative 
      • Female Mice Equivocal 
    • Dose: R: 0, 6700, 12100 M:0, 11700, 23500 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (770824)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (875607)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Weakly Positive 
  • Salmonella  (N-9357)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248