National Toxicology Program

National Toxicology Program

Testing Status of o-Cresol - 10455-P


CASRN: 95-48-7

Formula: C7-H8-O

Synonyms/Common Names

  • 2-Methylphenol

Known Uses

Chemical intermediate for epoxy resins, herbicides, dyes, disinfectant, solvent, pharmaceuticals, photography, paints, explosives, agricultural chemicals, obtained from coal tar (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Dosed-Feed)  (C62168)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C62168)  Report Complete 
    • TOX-09 (NIH Number: 92-3128)
      Toxicity Studies of Cresols (CASRNs 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M:0,.03,.1,.3,1.0,3.0%.

Genetic Toxicology

  • Micronucleus  (A02909)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (478797)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • Varies Immunotoxicity (Topical Application)  (IMM20710)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 0.5, 1, 2.5, 5, OR 10%.
  • 27 weeks Continuous Breeding (Legacy) (Dosed-Feed)  (RACB90001)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of Ortho-Cresol (OCRE) in CD-1 Swiss Mice when Administered in Feed
    • Mice: Swiss
    • Dose: 0,0.25,0.5,1.0,2.0,3.0%; 0,0.05,0.2,0.5%; N/A; 0,0.5%;.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.