National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10456-t

Testing Status of 1,2-Dichlorobenzene (o-dichlorobenzene) - 10456-T

 

CASRN: 95-50-1

Related: 1,3-DICHLOROBENZENE (541-73-1) & 1,4-DICHLOROBENZENE (106-46-7)

Formula: C6-H4-Cl2

Synonyms/Common Names

  • Benzene, 1,2-Dichloro- (9Ci)

Known Uses

Fumigant. Insecticide. Industrial solvent. Chemical intermediate. Degreasing agent for metals. Heat transfer medium. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C54944A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54944A)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C54944A)  Report Complete 
    • TR-255 (NIH Number: 86-2511)  (Peer Review Approval 09/22/1982A )
      Toxicology and Carcinogenesis Studies of 1,2-Dichlorobenzene (o-Dichlorobenzene) (CASRN 95-50-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Water; Intraperitoneal Injection)  (S0062)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (388032)  Completed 
    • Mice
    •  Positive 
  • Chromosome Aberrations  (732739)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (059536)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (934439)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (881718)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Positive 
  • Micronucleus  (279592)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (749046)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A44739)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (917014)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Sister Chromatid Exchanges  (388032)  Completed 
    • Mice
    • Sister Chromatid  Negative 
  • Sister Chromatid Exchanges  (732739)  Completed 
    • Mice
    • Sister Chromatid  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.