National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10464-t

Testing Status of Styrene oxide - 10464-T

 

CASRN: 96-09-3

Formula: C8-H8-O

Synonyms/Common Names

  • Phenyloxirane (9CI)

Known Uses

Chemical intermediate, reactive diluent for epoxy resins, intermediate in cosmetics, treatment of textiles. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13-Week (Gavage)  (C54977)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 108 weeks (Gavage)  (C54977)  Report Complete 
    •   (Peer Review Approval NA) Citation: W Lijinsky. Rat and Mouse Forestomach Tumors Induced by Chronic Oral Administration of Styrene Oxide. J Natl Cancer Inst. 1986 Aug;77(2):471-6.
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 275, 550 MG/KG.

Genetic Toxicology

  • Mouse Lymphoma  (692229)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (119335)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

Organ Systems Toxicity

  • 5 days/week for 3 weeks before breeding, or 1 to 19 GD, or 3 weeks before breeding plus 1 to 19 GD Conventional Teratology (Inhalation)  (T0040A)  Completed 
    • Citation: Teratologic Assessment of Butylene Oxide, Styrene Oxide, Methylbromide
    • Female Rats: Wistar
    • Dose: 100 ppm 7 hr/day.
  • 1 to 24 GD Conventional Teratology (Inhalation)  (T0040B)  Completed 
    • Citation: Teratologic Assessment of Butylene Oxide, Styrene Oxide, Methylbromide
    • Female Rabbit: New Zealand White
    • Dose: 15, 50 ppm 7 hr/day.
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