Testing Status of 1,2-Dibromo-3-chloropropane 10465-X

 

CASRN: 96-12-8

Formula: C3-H5-Br2-Cl

Synonyms/Common Names

  • DBCP
  • Propane, 1,2-dibromo-3-chloro-

Known Uses

Soil fumigant. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C00500B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Gavage)  (C00500A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 25, 160, M: 0, 100, 631 MG/KG/5 PER GROUP.
  • 13-Week (Inhalation)  (C00500B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 1.0, 25.0 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C00500A)  Report Complete 
    • TR-028 (NIH Number: 78-828)  (Peer Review Approval 09/26/1977A )
      Bioassay of Dibromochloropropane for Possible Carcinogenicity (CASRN 96-12-8)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R:0, 15, 29 MM:0, 114, 219 FM:0, 110, 209 MG/KG/50 PER GROUP.
  • 2-Year (Inhalation)  (C00500B)  Report Complete 
    • TR-206 (NIH Number: 82-1762)  (Peer Review Approval 06/27/1980A )
      Carcinogenesis Bioassay of 1,2-Dibromo-3-chloropropane (CASRN 96-12-8) in F344 Rats and B6C3F1 Mice (Inhalation Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0, 0.6, 3.0 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (063791)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (019787)  Completed 
    • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (652497)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Mouse Lymphoma  (063691)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Positive 
  • Micronucleus  (158710)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (197399)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
  • Sister Chromatid Exchanges  (063791)  Completed 
    • Mice
    • Sister Chromatid  Equivocal 

Organ Systems Toxicity

  • Dominant Lethal (Female) (Intraperitoneal Injection)  (DLF019)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., and Hughes, L.A. Tests for dominant Lethal effects of 1,2-dibromo-2-chloropropane in male and female mice. Mutation Res. 156:103-108 (1985).
    • Female Mice: C3H X C57BL
    • Mice Female Negative 
  • Dominant Lethal (Male) (Intraperitoneal Injection)  (DLM018)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., and Hughes, L.A. Tests for dominant Lethal effects of 1,2-dibromo-2-chloropropane in male and female mice. Mutation Res. 156:103-108 (1985).
    • Male Mice: C3H X 101
    • Mice Male Negative 
  • Morphological Specific Locus (Gavage)  (MSLM66)  Completed 
    • Citation: Russell, L.B., Hunsicker, R.R., and Cacheiro, N.L.A. Mouse specific locus test for the induction of heritable gene mutations by dibromochloropropane (DBCP). Mutation Res. 170:161-166 (1986).
    • Male Mice: 101 X C3H
  • 120 day minimum Continuous Breeding (Legacy) (Gavage)  (RACB82083)  Completed 
    • Citation: Final Report - Dibromochloropropane: Reproduction and Fertility Assessment in CD-1 Mice When Administered by Gavage
    • Male and Female Mice: Swiss
    • Dose: 0, 16.25, 32.5, 65, 130, 260 MG/KG/D; 0, 25, 50, 100 MG/KG/D; N/A; 0, 100 MG/KG/DAY.
  • Total Reproductive Capacity (Gavage)  (TRC98011)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice: B6C3F1/N
    • Mice Female Negative