National Toxicology Program

National Toxicology Program

Testing Status of Tri-o-cresyl Phosphate - 10469-N


CASRN: 78-30-8

Formula: C21-H21-O4-P

Synonyms/Common Names

  • Phosphoric acid, tris(2-methylphenyl) ester (9CI)
  • Triorthycresyl phosphate

Known Uses

Plasticizer in lacquers and varnishes, as lubricating oil additive, in manufacture of drugs

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0214)  Completed 
    • Citation: Pharmacokinetics of three Tri-Cresyl Phosphates in the Fischer 344 male rats: Tri-Ortho-Cresyl Phosphate, Tri-Meta Cresyl Phosphate, Tri-Para-Cresyl Phosphate.
    • Male Rats: F344/N
  • Metabolism  (S0789)  Completed 
    • Citation: Chapin RE, Phelps JL, Burka LT, Abou-Donia MB, Heindel JJ. The effects of tri-o-cresyl phosphate and metabolites on rat Sertoli cell function in primary culture. Toxicol Appl Pharmacol. 1991 Apr;108(2):194-204.Pubmed Abstract
    • Male Rats
  • Metabolism (in-vitro)  (S0790)  Completed 
    • Citation: Chapin RE, Phelps JL, Somkuti SG, Heindel JJ, Burka LT. The interaction of Sertoli and Leydig cells in the testicular toxicity of tri-o-cresyl phosphate. Toxicol Appl Pharmacol. 1990 Jul;104(3):483-95.Pubmed Abstract
    • Rats: Sprague Dawley
  • C. elegans  (W10469)  Completed 
    • C. elegans

Organ Systems Toxicity

  • Neurotoxicology Assessment (Gavage)  (NTA94008)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male and Female Rats/Mice: F344/N
  • 7 days, 10 days or 14 days Spermiation Inhibition (Gavage)  (RACB93160)  Completed 
    • Male Rats: F344/N
    • Dose: </= 150 MG/KG.
  • 8 to 15 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0027)  Completed 
    • Female Mice: Swiss
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.