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Testing Status of Tri-o-cresyl Phosphate 10469-N

 

CASRN: 78-30-8

Formula: C21-H21-O4-P

Synonyms/Common Names

  • Phosphoric acid, tris(2-methylphenyl) ester (9CI)
  • Triorthycresyl phosphate

Known Uses

Plasticizer in lacquers and varnishes, as lubricating oil additive, in manufacture of drugs

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0214)  Completed 
    • Citation: Pharmacokinetics of three Tri-Cresyl Phosphates in the Fischer 344 male rats: Tri-Ortho-Cresyl Phosphate, Tri-Meta Cresyl Phosphate, Tri-Para-Cresyl Phosphate.
    • Male Rats: F344/N
    • Dose: ORAL: 2.0, 20.0 & 200.0 mg/kg. intravenously - 20.0 mg/kg.
  • Metabolism  (S0789)  Completed 
    • Citation: Chapin RE, Phelps JL, Burka LT, Abou-Donia MB, Heindel JJ. The effects of tri-o-cresyl phosphate and metabolites on rat Sertoli cell function in primary culture. Toxicol Appl Pharmacol. 1991 Apr;108(2):194-204.Pubmed Abstract
    • Male Rats
  • Metabolism (in-vitro)  (S0790)  Completed 
    • Citation: Chapin RE, Phelps JL, Somkuti SG, Heindel JJ, Burka LT. The interaction of Sertoli and Leydig cells in the testicular toxicity of tri-o-cresyl phosphate. Toxicol Appl Pharmacol. 1990 Jul;104(3):483-95.Pubmed Abstract
    • Rats: Sprague Dawley
  • C. elegans  (W10469)  Completed 
    • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
    • C. elegans
    • Dose: Growth: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uMRepro: 0, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uMFeeding: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM.

Organ Systems Toxicity

  • Neurotoxicology Assessment (Gavage)  (NTA94008)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male and Female Rats/Mice: F344/N
  • 7 days, 10 days or 14 days Spermiation Inhibition (Gavage)  (RACB93160)  Completed 
    • Male Rats: F344/N
    • Dose: </= 150 MG/KG.
  • 8 to 15 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0027)  Completed 
    • Female Mice: Swiss