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Testing Status of p-Chloro-a,a,a-trifluorotoluene 10472-T

 

CASRN: 98-56-6

Formula: C7-H4-Cl-F3

Synonyms/Common Names

  • Benzene, 1-chloro-4-(trifluoromethyl)-
  • 1-Chloro-4-(trifluoromethyl)benzene
  • CTFT
  • PCBTF
  • p-Chlorobenzotrifluoride
  • PCTFT

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C88002B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 50, 500, or 1000 mg/kg/15 per group; includes 5 additional male rats per group for special studies: ELISA; prep of H&E, and Mallory's Heidenhain stained kidney sections for microscopic examination, hyaline droplets; CTFT levels in blood, kidney, liver.
  • 2 weeks (Gavage)  (C88002)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: Dose: R&M: 0, 50, 500, or 1000 mg/kg/15 per group; includes 5 additional male rats per group for special studies: ELISA; prep of H&E, and Mallory's Heidenhain stained kidney sections for microscopic examination, hyaline droplets; CTFT levels in blood, kidney, liver.
  • 90 days (Inhalation)  (C10472)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R&M: 0, 125, 250, 500, 1000, or 2000 ppm; 10/sex/dose.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C10472B)  Completed 
    • TR-594   (Peer Review Approval 07/13/2017A )
      Toxicology and Carcinogenesis Studies of p-Chloro-a,a,a-trifluorotoluene (CASRN 98-56-6) in Sprague Dawley Rats (Hsd:Sprague Dawley SD) and B6C3F1/N Mice (Inhalation Studies)
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 100, 300, or 1000 ppm; M: 0, 100, 200, or 400 ppm; 50/sex/species.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0406)  Completed 
    • Citation: Yuan JM, Jameson CW, Goehl TJ, Collins BJ, Purdie W, Judd L. Application of molecular encapsulation for toxicology studies: toxicokinetics of p-chloro-alpha,alpha,alpha-trifluorotoluene in alpha-cyclodextrin or corn oil vehicles in male F344 rats. Toxicol Appl Pharmacol. 1991 Oct;111(1):107-15. Pubmed Abstract
    • Male Rats: F344/N
    • Dose: Corn oil: 10, 50, or 400 mg/kg. Alpha-cyclodextrin: 10, 50, 200, or 400 mg/kg.

Genetic Toxicology

  • Micronucleus  (G10472B)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Equivocal 
  • Micronucleus  (G10472)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Equivocal 
    • Female Negative 
  • Salmonella  (176994)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (G10472C)  On Test 

    Organ Systems Toxicity

    • Continuous Breeding (Inhalation) Selected (R10472)  
      • Male and Female Rats: Harlan Sprague-Dawley