National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10472-t

Testing Status of p-Chloro-a,a,a-trifluorotoluene - 10472-T

 

CASRN: 98-56-6

Formula: C7-H4-Cl-F3

Synonyms/Common Names

  • Benzene, 1-chloro-4-(trifluoromethyl)-
  • 1-Chloro-4-(trifluoromethyl)benzene
  • CTFT
  • PCBTF
  • p-Chlorobenzotrifluoride
  • PCTFT

Known Uses

Dye intermediate; solvent & dielectric fluid; intermediate for herbicides

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C88002B)  Report Complete 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 50, 500, 1000 MG/KG/15 PER GROUP; INCLUDES 5 ADDITIONAL MALE RATS PER GRP FOR SPEC. STUDIES SPECIAL STUDIES: ELISA; PREP OF H&E AND MALLORY'S HEIDENHAIN STAINED KIDNEY SECTIONS FOR MICROS. EXAM, HYALINE DROPLET; CTFT LEVEL BL, KID, LIV.
  • 2 weeks (Gavage)  (C88002)  Report Complete 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 50, 500, 1000 mg/kg/15 per group includes 5 add'l male rats per group for special studies: ELISA; prep. of H&E and Mallory's Heidenhain stained kidney sections for micros. exam, hyaline droplets; CTFT levels in blood, kidney, liv.
  • 90 days (Inhalation)  (C10472)  Report Draft 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R&M: 0, 125, 250, 500, 1000, or 2000 ppm; 10/sex/dose.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C10472B)  Report Draft 
    • TR-594
      Toxicology and Carcinogenesis Studies of p-Chloro-a,a,a-trifluorotoluene (CASRN 98-56-6) in Harlan Sprague-Dawley Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R: 0, 100, 300, or 1000 ppm; M: 0, 100, 200, or 400 ppm; 50/sex/species.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0406)  Completed 
    • Citation: Yuan JM, Jameson CW, Goehl TJ, Collins BJ, Purdie W, Judd L. Application of molecular encapsulation for toxicology studies: toxicokinetics of p-chloro-alpha,alpha,alpha-trifluorotoluene in alpha-cyclodextrin or corn oil vehicles in male F344 rats. Toxicol Appl Pharmacol. 1991 Oct;111(1):107-15. Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • Micronucleus  (G10472B)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Equivocal 
  • Micronucleus  (G10472)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Equivocal 
    • Female Negative 
  • Salmonella  (176994)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (G10472C)  On Test 

    Organ Systems Toxicity

    • Continuous Breeding (Inhalation) Selected (R10472)  
      • Male and Female Rats: Harlan Sprague-Dawley
    • Conventional Teratology (Inhalation) Selected (R10472B)  
      NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.