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Testing Status of alpha-Methylbenzyl alcohol 10473-X

 

CASRN: 98-85-1

Formula: C8-H10-O

Synonyms/Common Names

  • alpha-Methylbenzenemethanol (9CI)

Known Uses

Flavoring agent. Fragrances. Lab reagent. Intermediate in styrene production. Dyes. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55685)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55685)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 93, 1500, M: 0, 46.9, 750 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55685)  Completed 
    • TR-369 (NIH Number: 89-2824)  (Peer Review Approval 03/13/1989A )
      Toxicology and Carcinogenesis Studies ofa-Methylbenzyl Alcohol (CASRN 98-85-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 375, 750 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (870290)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (570080)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (377758)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative