National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10478-s

Testing Status of 4-Chloronitrobenzene - 10478-S

 

CASRN: 100-00-5

Formula: C6-H4-Cl-N-O2

Synonyms/Common Names

  • 1-Cloro-4-nitrobenzene
  • p-Chloronitrobenzene

Known Uses

Intermediate in the manufacture of dyes, parathion, agricultural chemicals and rubber chemicals. End products made from 4-cnb include carbamate pesticides, sulfur and azo-fast dyes, pharmaceuticals, rubber chemicals, antioxidants, gas gum inhibitors, corrosion inhibitors, photographic chemicals and acetaminophen. (exec sum 9/86)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C62259)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: O, 1.5, 3.0, 6.0, 12.0, 0R 24 PPM (5/S/S).
  • 13 weeks (Inhalation)  (C62259)  Report Complete 
    • TOX-33 (NIH Number: 93-3382)
      Toxicity Studies of 2-Chloronitrobenzene (CASRN 88-73-3) and 4-Chloronitrobenzene (CASRN 100-00-5) Administered by Inhalation to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 1.5, 3, 6, 12, OR 24 PPM (10/S/S).

Special Studies

  • Absorption Disposition Metabolism Elimination (Topical Application)  (S0077)  Completed 
    • Citation: Effect of Dose on the Extent of Absorption of 4-Chloronitrobenzene in Rats after Dermal Administration March 1991
    • Male Rats: F344/N
    • Dose: 0.65, 6.5, 65 MG/KG.
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0105)  Completed 
    • Male Rats: F344/N
    • Dose: 2, 20, 200 MG/KG.
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0363)  Completed 
    • Citation: Effect of Pretreatment with Chloronitrobenzene on the Disposition and Metabolism of 4-Chlorobenzene in Geriatric Male Fischer 344 Rats.
    • Male Rats: F344/N
    • Dose: 65 MG/KG.
  • Absorption Disposition Metabolism Elimination  (S0779)  Completed 
    • Citation: Effect of Repeated Dosing on the Disposition and Metabolism of 4-Chloronitrobenzene in Rats after Oral Administration.
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (565306)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (234975)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (809177)  Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (A13548)  Completed 
    • Mice
    • Male Not a Valid Test 
    • Female Not a Valid Test 
  • Salmonella  (300619)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (975957)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 

Organ Systems Toxicity

  • greater than 120 days Continuous Breeding (Legacy) (Gavage)  (RACB19077)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of 4-Chloronitrobenzene in CD-1 Swiss Mice
    • Male and Female Mice: Swiss
    • Dose: 0, 40, 80, 160, 320, 640 MG/KG; 0, 62.5, 250 MG/KG; N/A; 0, 250 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.