National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10481-x

Testing Status of Benzyl chloride - 10481-X

 

CASRN: 100-44-7

Formula: C7-H7-Cl

Synonyms/Common Names

  • (Chloromethyl)benzene

Known Uses

Intermediate In manufacture of perfumes, drugs, dyes, resins (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13-Week (Gavage)  (C06360)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 108 weeks (Gavage)  (C06360)  Report Complete 
    •   (Peer Review Approval NA) Citation: W Lijinsky, Chronic Bioassay of Benzyl Chloride in F344 Rats and (C57BL/6JXBALB/C)F1 Mice. J Natl Cancer Inst. 1986 Jun;76(6):1231-6.
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 15, 30, M: 0, 50, 100 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (186977)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (057128)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Salmonella  (422540)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Weakly Positive 
  • Salmonella  (723160)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Weakly Positive 
  • Salmonella  (G10481)  Completed 
    •  Weakly Positive 
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