National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10488-a

Testing Status of 4,4'-Diphenylmethane diisocyanate - 10488-A

 

CASRN: 101-68-8

Formula: C15-H10-N2-O2

Synonyms/Common Names

  • 1,1'-Methylenebis(4-isocyanatobenzene)

Known Uses

Manufacture of high molecular weight polyurethane and other isocyanate-derived polymers. In preparation of spandex fibers. Adhesive for bonding rubber to rayon and nylon. (NTP executive summary)

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (111338)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.