National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10492-j

Testing Status of Diglycidyl resorcinol ether (DGRE) - 10492-J

 

CASRN: 101-90-6

Formula: C12-H14-O4

Synonyms/Common Names

  • DGRE
  • 2,2'-(1,3-Phenylenebis(oxymethylene))bisoxirane

Known Uses

Diluent in production of epoxy resins; liquid spray epoxy resin; used in electrical, tooling, adhesive, and laminating applications; curing agent for polysulfide rubber

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C54966A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54966A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,12.5,200, M: 0,25,400 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C54966A)  Report Complete 
    • TR-257 (NIH Number: 87-2513)  (Peer Review Approval 02/28/1983A )
      Toxicology and Carcinogenesis Studies of Diglycidyl Resorcinol Ether (Technical Grade) (CASRN 101-90-6) In F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,12,25,50, M: 0,50,100 PPM/50 PER GROUP.
  • 2-Year (Gavage)  (C54966A)  Report Complete 
    • TR-257 (NIH Number: 87-2513)  (Peer Review Approval 02/28/1983A )
      Toxicology and Carcinogenesis Studies of Diglycidyl Resorcinol Ether (Technical Grade) (CASRN 101-90-6) In F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,12,25,50, M: 0,50,100 PPM/50 PER GROUP.

Special Studies

  • Cell Proliferation (Gavage)  (S0758)  Completed 
    • Citation: Ghanayem BI, Maronpot RR, Matthews HB. Association of chemically induced forestomach cell proliferation and carcinogenesis. Cancer Lett. 1986 Sep;32(3):271-8.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (389996)  Completed 
    • Mice
    •  Positive 
  • Chromosome Aberrations  (873378)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (120506)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (586624)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Mouse Lymphoma  (195111)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Micronucleus  (367536)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A56274)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (493700)  Completed 
    • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
    •  Positive 
  • Sister Chromatid Exchanges  (389996)  Completed 
    • Mice
    • Sister Chromatid  Positive 
  • Sister Chromatid Exchanges  (873378)  Completed 
    • Mice
    • Sister Chromatid  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.