National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10496-a

Testing Status of Triethanolamine - 10496-A

 

CASRN: 102-71-6

Formula: C6-H15-N-O3

Synonyms/Common Names

  • 2,2',2''-Nitrilotriethanol

Known Uses

Intermediate in manufacture surfactants, textile specialties, waxes, polishes, herbicides, petroleum demulsifiers, toilet goods, cement additives, cutting oils, in making mineral & vegetable oil emulsions, solvent, pharmaceutic aid (alkalizer) (Merck 1989). Is widely used as an ingredient in emulsifiers, thickeners, wetting agents, detergents, and alkalinizing agents in cosmetic products; as a chemical intermediate for anionic and nonionic surfactants and surface active agents in household cleaning agents, textiles, herbicides, pharmaceutical ointments, and other products; as a vulcanization accelerator in the manufacture of rubber; and in many other industrial applications.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Water)  (C61621A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 2 weeks (Topical Application)  (C61621B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 14-Day (Inhalation)  (C61621C)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 3 weeks (Topical Application)  (C61621D)  Completed 
    • Rats: F344/N; Mice: B6C3F1; Mice: Sencar
  • 13 weeks (Topical Application)  (C61621B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,0.125,0.25,0.5,1,2 G/KG M: 0.25,0.5,1,2,4 G/KG.

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C61621D)  Report Complete 
    • TR-449 (NIH Number: 00-3365)  (Peer Review Approval 10/30/1998A )
      Toxicology and Carcinogenesis Studies of Triethanolamine (CASRN 102-71-6) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice Inadequate Study 
      • Female Mice Inadequate Study 
    • Dose: MR: 0, 32, 63, OR 125; FR: 0, 63, 125, OR 250; MM: 0, 200, 630, OR 2000; FM: 0, 100, 300, OR 1000 MG/KG; 60/GROUP.
  • 2 years (Topical Application)  (C61621E)  Report Complete 
    • TR-518 (NIH Number: 04-4452)  (Peer Review Approval 05/22/2003A )
      Toxicology and Carcinogenesis Studies of Triethanolamine (CASRN 102-71-6) in B6C3F1 Mice (Dermal Studies)
    • Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Mice Equivocal Evidence 
      • Female Mice Some Evidence 
    • Dose: MM: 0, 200, 630, OR 2000 MG/KG; FM: 0, 100, 300, OR 1000 MG/KG.

Special Studies

  • Absorption Disposition Metabolism Elimination (Intravenous; Topical Application)  (S0652)  Completed 
    • Female Rats: F344/N; Female Mice: B6C3F1; Female Rats: F344/N; Female Mice: B6C3F1

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (932037)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (771013)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (A38253)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (683120)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (IMM90005)  Completed 
    • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15
    • Female Mice: B6C3F1
  • 10 weeks (Mating trial study - rats were bred for a maximum of 10 days starting at the beginning of the eleventh week of dosing -- April 6 - April 15, 1988) Continuous Breeding (Legacy) (Topical Application)  (RACB89001)  Completed 
    • Male and Female Rats: F344/N
    • Dose: 0, 0.125, 0.25, OR 0.5 G/KG.
  • 10 weeks (Mating trial study - mice were bred for a maximum of 10 days starting at the beginning of the eleventh week of dosing -- February 22 - March 2, 1988) Continuous Breeding (Legacy) (Topical Application)  (RACB89002)  Completed 
    • Male and Female Mice: Swiss CD-1
    • Dose: 0, 0.5, 1.0, OR 2.0 G/KG.
  • 8 to 15 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0052)  Completed 
    • Female Mice: Swiss
  • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP90013)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 100, 500, 1000, 2500, OR 5000 MG/KG.
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