Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Triethanolamine 10496-A

 

CASRN: 102-71-6

Formula: C6-H15-N-O3

Synonyms/Common Names

  • 2,2',2''-Nitrilotriethanol

Known Uses

Intermediate in manufacture surfactants, textile specialties, waxes, polishes, herbicides, petroleum demulsifiers, toilet goods, cement additives, cutting oils, in making mineral & vegetable oil emulsions, solvent, pharmaceutic aid (alkalizer) (Merck 1989). Is widely used as an ingredient in emulsifiers, thickeners, wetting agents, detergents, and alkalinizing agents in cosmetic products; as a chemical intermediate for anionic and nonionic surfactants and surface active agents in household cleaning agents, textiles, herbicides, pharmaceutical ointments, and other products; as a vulcanization accelerator in the manufacture of rubber; and in many other industrial applications.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Water)  (C61621A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 2 weeks (Topical Application)  (C61621B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 14-Day (Inhalation)  (C61621C)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 3 weeks (Topical Application)  (C61621D)  Completed 
    • Rats: F344/N; Mice: B6C3F1; Mice: Sencar
  • 13 weeks (Topical Application)  (C61621B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 0.125, 0.25, 0.5, 1, 2 G/KG M: 0.25, 0.5, 1, 2, 4 G/KG.

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C61621D)  Completed 
    • TR-449 (NIH Number: 00-3365)  (Peer Review Approval 10/30/1998A )
      Toxicology and Carcinogenesis Studies of Triethanolamine (CASRN 102-71-6) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice Inadequate Study 
      • Female Mice Inadequate Study 
    • Dose: MR: 0, 32, 63, OR 125; FR: 0, 63, 125, OR 250; MM: 0, 200, 630, OR 2000; FM: 0, 100, 300, OR 1000 MG/KG; 60/GROUP.
  • 2 years (Topical Application)  (C61621E)  Completed 
    • TR-518 (NIH Number: 04-4452)  (Peer Review Approval 05/22/2003A )
      Toxicology and Carcinogenesis Studies of Triethanolamine (CASRN 102-71-6) in B6C3F1 Mice (Dermal Studies)
    • Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Mice Equivocal Evidence 
      • Female Mice Some Evidence 
    • Dose: MM: 0, 200, 630, OR 2000 MG/KG; FM: 0, 100, 300, OR 1000 MG/KG.

Special Studies

  • Absorption Disposition Metabolism Elimination (Intravenous; Topical Application)  (S0652)  Completed 
    • Female Rats: F344/N; Female Mice: B6C3F1; Female Rats: F344/N; Female Mice: B6C3F1
    • Dose: IV: 3 mg/kg in rats and mice; dermal: rats: 68-276 mg/kg on a 12 cm2 dose site, mice: 79-1120 mg/kg on a 1.44 com2.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (932037)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (771013)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (A38253)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (683120)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (IMM90005)  Completed 
    • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15
    • Female Mice: B6C3F1
    • Dose: 0, 3, 10, 30%.
  • 10 weeks (Mating trial study - rats were bred for a maximum of 10 days starting at the beginning of the eleventh week of dosing -- April 6 - April 15, 1988) Continuous Breeding (Legacy) (Topical Application)  (RACB89001)  Completed 
    • Male and Female Rats: F344/N
    • Dose: 0, 0.125, 0.25, OR 0.5 G/KG.
  • 10 weeks (Mating trial study - mice were bred for a maximum of 10 days starting at the beginning of the eleventh week of dosing -- February 22 - March 2, 1988) Continuous Breeding (Legacy) (Topical Application)  (RACB89002)  Completed 
    • Male and Female Mice: Swiss CD-1
    • Dose: 0, 0.5, 1.0, OR 2.0 G/KG.
  • 8 to 15 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0052)  Completed 
    • Female Mice: Swiss
  • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP90013)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 100, 500, 1000, 2500, OR 5000 MG/KG.