National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10500-k

Testing Status of 1-Phenyl-2-thiourea - 10500-K

 

CASRN: 103-85-5

Formula: C7-H8-N2-S

Synonyms/Common Names

  • Phenylthiourea (9CI)

Known Uses

Genetics research

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02017)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02017)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C02017)  Report Complete 
    • TR-148 (NIH Number: 78-1704)  (Peer Review Approval 06/25/1978A )
      Bioassay of 1-Phenyl-2-thiourea for Possible Carcinogenicity (CASRN 103-85-5)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (575473)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (688781)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (155526)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
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