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Testing Status of Caprolactam 10505-F

 

CASRN: 105-60-2

Formula: C6-H11-N-O

Synonyms/Common Names

  • Hexahydro-2H-azepin-2-one (9CI)

Known Uses

Monomer for polycaprolactam (Nylon 6), manufacture of polyamide synthetic fibers

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C50646)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C50646)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 625, 750, M: 0, 5000, 30000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C50646)  Completed 
    • TR-214 (NIH Number: 81-1770)  (Peer Review Approval 06/27/1980A )
      Carcinogenesis Bioassay of Caprolactam (CASRN 105-60-2) in F344 Rats and B6C3F1 Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 3750, 7500, M: 0, 7500, 15000 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (201538)  Completed 
    • Citation: McFee, A.F., and Lowe, K.W. Caprolactam and benzoin: tests for induction of chromosome aberrations and sister-chromatid exchanges in mouse bone marrow. Mutation Res. Vol. 224 (1989) 347-350
    • Mice
    •  Negative (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (641268)  Completed 
    • Citation: Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (650562)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (127633)  Completed 
    • Citation: Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
    • Mice
    •  Negative 
  • Micronucleus  (222213)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (572383)  Completed 
    • Citation: Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
    •  Negative 
  • Sister Chromatid Exchanges  (201538)  Completed 
    • Citation: McFee, A.F., and Lowe, K.W. Caprolactam and benzoin: tests for induction of chromosome aberrations and sister-chromatid exchanges in mouse bone marrow. Mutation Res. Vol. 224 (1989) 347-350
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol)