National Toxicology Program

National Toxicology Program

Testing Status of p-Cresol - 10509-W


CASRN: 106-44-5

Formula: C7-H8-O

Synonyms/Common Names

  • 4-Methylphenol

Known Uses

Intermediate in production of disinfectants, explosives, synthetic perfumery, metal cleaners, synthetic flavors, obtained from coal tar (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Dosed-Feed)  (C62180)  Report Complete 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,300,1000,3000,10000,30000 PPM/ 5 PER GROUP.

Genetic Toxicology

  • Salmonella  (388990)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.