Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Epichlorhydrin 10512-C


CASRN: 106-89-8

Formula: C3-H5-Cl-O

Synonyms/Common Names

  • alpha-Epichlorohydrin
  • Oxirane, (chloromethyl)-

Known Uses

Some use in food as food starch, also used in paints, resins, insecticide emulsions, solvent, co-monomer, nail enamels, in hair conditioners & surfactants (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • lifetime (Inhalation)  (C07001)  Completed 
    • Rats: Sprague Dawley
    • Dose: R: 0, 100 PPM /100 ANIMALS PER GROUP.

Genetic Toxicology

  • Comet Assay  (G10512B)  Completed 
    • Mice
  • In Vitro Cytogenetics (CA/SCE)  (099989)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (G10512)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (365601)  Completed 
    • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
    •  Positive