Testing Status of Epichlorhydrin 10512-C

 

CASRN: 106-89-8

Formula: C3-H5-Cl-O

Synonyms/Common Names

  • alpha-Epichlorohydrin
  • Oxirane, (chloromethyl)-

Known Uses

Some use in food as food starch, also used in paints, resins, insecticide emulsions, solvent, co-monomer, nail enamels, in hair conditioners & surfactants (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • lifetime (Inhalation)  (C07001)  Completed 
    • Rats: Sprague Dawley
    • Dose: R: 0, 100 PPM /100 ANIMALS PER GROUP.

Genetic Toxicology

  • Comet Assay  (G10512B)  Completed 
    • Mice
  • In Vitro Cytogenetics (CA/SCE)  (099989)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (G10512)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (365601)  Completed 
    • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
    •  Positive