National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10513-f

Testing Status of 1,2-Dibromoethane - 10513-F

 

CASRN: 106-93-4

Formula: C2-H4-Br2

Synonyms/Common Names

  • EDB
  • Ethylene dibromide

Known Uses

Scavenger for lead in gasoline; soil and grain fumigant; intermediate for dyes and drugs. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 14-Day (Inhalation)  (C00522B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Gavage)  (C00522A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: 0, 40, 251 MG/KG/5 PER GROUP.
  • 13-Week (Inhalation)  (C00522B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 3, 75 PPM/10R - 20M PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C00522A)  Report Complete 
    • TR-086 (NIH Number: 78-1336)  (Peer Review Approval 04/26/1978A )
      Bioassay of 1,2-Dibromoethane for Possible Carcinogenicity (CASRN 106-93-4)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: MR: 0, 38, 41 (AVG), FR: 0, 37, 39 (AVG), M: 0, 62, 107 MG/KG/50 PER GROUP.
  • 2-Year (Inhalation)  (C00522B)  Report Complete 
    • TR-210 (NIH Number: 82-1766)  (Peer Review Approval 06/27/1980A )
      Carcinogenesis Bioassay of 1,2-Dibromoethane (CASRN 106-93-4) in F344 Rats and B6C3F1 Mice (Inhalation Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0, 10, 40 PPM/50 PER GROUP.

Special Studies

  • Cell Proliferation (Gavage)  (S0762)  Completed 
    • Citation: Ghanayem BI, Maronpot RR, Matthews HB. Association of chemically induced forestomach cell proliferation and carcinogenesis. Cancer Lett. 1986 Sep;32(3):271-8.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (738945)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (665769)  Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (782145)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Mouse Lymphoma  (G50253)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Mouse Lymphoma  (G62050)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Micronucleus  (A71010)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (529327)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
  • Salmonella  (N-9282)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Sister Chromatid Exchanges  (738945)  Completed 
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol) 

Organ Systems Toxicity

  • Biochemical Specific Locus (Gavage)  (BSLM37)  Completed 
    • Citation: Barnett, L.B., Felton, C.F., Gibson, B.J., Sharpe, D.S., Shelby, M.D., and Lewis, S.E. No heritable mutations are induced by ethylene dibromide at electrophoretically expressed loci. Mutation Res. 282:127-133 (1992).
    • Male Mice: DBA/2J
    • Mice Male Negative 
  • Dominant Lethal (Male) (Dosed-Feed)  (DLM021)  Completed 
    • Citation: Barnett, L.B., Felton, C.F., Gibson, B.J., Sharpe, D.S., Shelby, M.D., and Lewis, S.E. No heritable mutations are induced by ethylene dibromide at electrophoretically expressed loci. Mutation Res. 282:127-133 (1992).
    • Male Mice: DBA/2J
    • Mice Male Negative 
  • Total Reproductive Capacity (Dosed-Feed)  (TRC98012)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice: B6C3F1
    • Mice Female Negative 
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