Testing Status of Acrolein 10515-N

 

CASRN: 107-02-8

Formula: C3-H4-O

Synonyms/Common Names

  • Acraldehyde
  • 2-Propenal

Known Uses

Intermediate for glycerin, polyurethane, polyester resins, methionine and various pharmaceuticals. Colloidal suspensions of metals. Military poison gas mixtures. Tissue fixative. Slimicide in paper manufacture. Control of aquatic weeds, jet fuels. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Gavage)  (C02802C)  Report Complete 
    • TOX-48 (NIH Number: 06-4413)
      Comparative Toxicity Studies of Allyl Acetate (CASRN 591-87-7), Allyl Alcohol (CASRN 107-18-6) and Acrolein (CASRN 107-02-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 0.75, 1.25, 2.5, 5, OR 10 MG/KG M: 0, 1.25, 2.5, 5, 10, OR 20 MG/KG; 10 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (134448)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (395759)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (472710)  Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (A59477)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (326814)  Completed 
    •  Negative 
  • Salmonella  (326815)  Completed 
    •  Negative 
  • Salmonella  (870479)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive