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Testing Status of Allyl chloride 10516-S

 

CASRN: 107-05-1

Formula: C3-H5-Cl

Synonyms/Common Names

  • 3-Chloro-1-propene

Known Uses

Preparation of glycerol, epichlorohydrin, pharmaceuticals, insecticides, resins for varnishes, plastics, adhesives

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04615)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C04615)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 56, 562, M: 0, 178, 1780 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04615)  Completed 
    • TR-073 (NIH Number: 78-1323)  (Peer Review Approval 06/29/1978A )
      Bioassay of Allyl Chloride for Possible Carcinogenicity (CASRN 107-05-1)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Equivocal 
      • Female Mice Equivocal 
    • Dose: FR: 0, 55, 73 (AVG), MR: 0, 57, 77 (AVG), FM: 0, 129, 258 (AVG), MM: 0, 172, 199 (AVG) MG/KG/50 PER GROUP.

Genetic Toxicology

  • Salmonella  (096311)  Completed 
    • Citation: McGregor, D.B., Reynolds, D.M., and Zeiger, E. Conditions affecting the mutagenicity of trichloroethylene in Salmonella Environ. Molec. Mutagen. Vol. 13 (1989) 197-202
    •  Positive 

Organ Systems Toxicity

  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0057)  Completed 
    • Citation: Screening of Priority Chemicals for Reproductive Hazards
    • Female Mice: Swiss
    • Dose: 500 MG/KG BODY WEIGHT.