National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10517-w

Testing Status of 2-Chloroethanol (ethylene chlorohydrin) - 10517-W

 

CASRN: 107-07-3

Formula: C2-H5-Cl-O

Synonyms/Common Names

  • Ethanol, 2-chloro-
  • Ethylene chlorohydrin

Known Uses

Chemical intermediate. Solvent. Manufacture of insecticides.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Topical Application)  (C50135)  Completed 
    • Rats: F344/N; Mice: Swiss
  • 13-Week (Topical Application)  (C50135)  Completed 
    • Rats: F344/N; Mice: Swiss
    • Dose: R: 0, 62, 1000, M: 0, 50, 450 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Topical Application)  (C50135)  Report Complete 
    • TR-275 (NIH Number: 86-2531)  (Peer Review Approval 07/27/1984A )
      Toxicology and Carcinogenesis Studies of 2-Chloroethanol (Ethylene Chlorohydrin) (CASRN 107-07-3) in F344/N Rats and Swiss CD-1 Mice (Dermal Studies)
    • Rats: F344/N; Mice: Swiss
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 50, 100, M: 0, 7.5, 15 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (208472)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (165108)  Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (595891)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (951597)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Micronucleus  (666681)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (051370)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (052370)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (552370)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Sister Chromatid Exchanges  (208472)  Completed 
    • Mice
    • Sister Chromatid  Negative 
  • Sister Chromatid Exchanges  (495716)  Completed 
    • Mice
    • Sister Chromatid  Negative 

Organ Systems Toxicity

  • 4 to 6 GD Conventional Teratology (Intravenous)  (TER84070A)  Completed 
    • Citation: Teratologic Evaluation of Ethylene Chlorohydrin (CASRN 107-07-3) in CD-1 Mice
    • Female Mice: Swiss CD-1
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 60, 120 MG/KG/DAY.
  • 6 to 8 GD Conventional Teratology (Intravenous)  (TER84070B)  Completed 
    • Citation: Teratologic Evaluation of Ethylene Chlorohydrin (CASRN 107-07-3) in CD-1 Mice
    • Female Mice: Swiss CD-1
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 60, 120 MG/KG/DAY.
  • 8 to 10 GD Conventional Teratology (Intravenous)  (TER84070C)  Completed 
    • Citation: Teratologic Evaluation of Ethylene Chlorohydrin (CASRN 107-07-3) in CD-1 Mice
    • Female Mice: Swiss CD-1
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 60, 120 MG/KG/DAY.
  • 10 to 12 GD Conventional Teratology (Intravenous)  (TER84070D)  Completed 
    • Citation: Teratologic Evaluation of Ethylene Chlorohydrin (CASRN 107-07-3) in CD-1 Mice
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 60, 120 MG/KG/DAY.
  • 6 to 14 GD Conventional Teratology (Intravenous)  (TER84071)  Completed 
    • Citation: Teratologic Evaluation of Ethylene Chlorohydrin (CASRN 107-07-3) in New Zealand White Rabbits
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Negative 
    • Rabbits Fetal Negative 
    • Dose: 9, 18, 36 MG/KG/D.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.