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Testing Status of Succinic anhydride 10518-A

 

CASRN: 108-30-5

Formula: C4-H4-O3

Synonyms/Common Names

  • Dihydro-2,5-furandione (9CI)

Known Uses

Food industry as dehydrator and acidulant. Chemical intermediate for adhesives, dyes, elastomers for special tubing, covering and extruded articles. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55696A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55696A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R:0, 12.5, 400 M:0, 37, 600 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55696A)  Completed 
    • TR-373 (NIH Number: 89-2828)  (Peer Review Approval 06/27/1989A )
      Toxicology and Carcinogenesis Studies of Succinic Anhydride (CASRN 108-30-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R:0, 50, 100 MM: 0, 38, 75, FM: 0, 75, 150 MG/KG/60 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (690556)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (088436)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (239833)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative