National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10523-n

Testing Status of bis(2-Chloro-1-methylethyl) ether - 10523-N

 

CASRN: 108-60-1

Formula: C6-H12-Cl2-O

Synonyms/Common Names

  • Bis(2-chloroisopropyl) ether
  • Propane, 2,2'-oxybis(1-chloro-

Known Uses

Paint & varnish removers; intermediate in dyes, resins and pharmaceuticals; nematocide in Japan

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C50044A)  Completed 
    • Rats: F344/N
  • 13-Week (Gavage)  (C50044A)  Completed 
    • Rats: F344/N
    • Dose: 0, 10, 250 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C50044A)  Report Complete 
    • TR-191 (NIH Number: 79-1747)  (Peer Review Approval 05/01/1979A )
      Bioassay of Technical Grade Bis(2-chloro-1-methylethyl) ether for Possible Carcinogenicity (CASRN 108-60-1)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
    • Dose: 0, 100, 200 MG/KG/50 PER GROUP.
  • 2-Year (Gavage)  (C50044B)  Report Complete 
    • TR-239 (NIH Number: 83-1795)  (Peer Review Approval 12/16/1981A )
      Carcinogenesis Bioassay of Bis(2-chloro-1-methylethyl)ether (~70) (CASRN 108-60-1) Containing 2-Chloro-1-methylethyl(2-chloropropyl)ether (~30) (CASRN 83270-31-9) in B6C3F1 Mice (Gavage Study)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0, 100, 200 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (500655)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (453382)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (945998)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Mouse Lymphoma  (151175)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (035504)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Weakly Positive 
  • Salmonella  (082677)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (175248)  Completed 
    •  Positive 
  • Salmonella  (247021)  Completed 
    •  Positive 
  • Salmonella  (856126)  Completed 
    •  Positive 
  • Salmonella  (891894)  Completed 
    •  Positive 
  • Sister Chromatid Exchanges  (500655)  Completed 
    • Mice
    • Sister Chromatid  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.