National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10526-a

Testing Status of Isocyanuric acid - 10526-A

 

CASRN: 108-80-5

Formula: C3-H3-N3-O3

Synonyms/Common Names

  • Cyanuric acid
  • 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione (9CI)
  • Tricarbimide

Known Uses

Intermediate in the production of scouring powders, household bleaches, institutional and industrial cleansers, automatic dishwasher compounds, general sanitizers and for swimming pool disinfection. Used in the laboratory for the production of cyanic acid.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (K10526B)  Completed 
    • Citation: Jacob CC, Gamboa da Costa G. Low-level quantification of melamine and cyanuric acid in limited samples of rat serum by UPLC-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Mar 15;879(9-10):652-6. doi: 10.1016/j.jchromb.2011.01.035. Epub 2011 Feb 21.Pubmed Abstract
    • Citation: Jacob CC, Reimschuessel R, Von Tungeln LS, Olson GR, Warbritton AR, Hattan DG, Beland FA, Gamboa da Costa G. Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats. Toxicol Sci. 2011 Feb;119(2):391-7. doi: 10.1093/toxsci/kfq333. Epub 2010 Oct 28.Pubmed Abstract
    • Male and Female Rats: F344 (NCTR)
  • Toxicokinetic Study (Gavage)  (K10526)  Completed 
    • Citation: Jacob CC, Gamboa da Costa G. Low-level quantification of melamine and cyanuric acid in limited samples of rat serum by UPLC-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Mar 15;879(9-10):652-6. doi: 10.1016/j.jchromb.2011.01.035. Epub 2011 Feb 21.Pubmed Abstract
    • Citation: Jacob CC, Reimschuessel R, Von Tungeln LS, Olson GR, Warbritton AR, Hattan DG, Beland FA, Gamboa da Costa G. Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats. Toxicol Sci. 2011 Feb;119(2):391-7. doi: 10.1093/toxsci/kfq333. Epub 2010 Oct 28.Pubmed Abstract
    • Male and Female Rats: Fischer 344

Genetic Toxicology

  • Salmonella  (599477)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.