Testing Status of beta-Picoline 10530-J

 

CASRN: 108-99-6

Formula: C6-H7-N

Synonyms/Common Names

  • 3-Methylpyridine (9CI)
  • 3-Picoline

Known Uses

Used as a solvent in the synthesis of pharmaceuticals, resins, dyes & rubber accelerators and as a lab reagent. Also used as an intermediate in the manufacture of insecticides, waterproofing agents, niacin & niacinamide.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C20009)  Report Complete 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 78, 156, 312, 625, or 1250 mg/l; R: 20/sex/dose; M: 10/sex/dose.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C20009)  Report Complete 
    • TR-580 (NIH Number: 14-5922)  (Peer Review Approval 02/08/2012A )
      Toxicology and Carcinogenesis Studies of β-Picoline (CASRN 108-99-6) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Some Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 156.25, 312.5, or 625 mg/l M: 0, 312.5, 625, or 1250 mg/l; 50/sex/species/dose.

Genetic Toxicology

  • Micronucleus  (A31463)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (421607)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (A73702)  Completed 
    •  Negative 
  • Salmonella  (A80302)  Completed 
    •  Negative