Testing Status of Pyridine 10532-S

 

CASRN: 110-86-1

Formula: C5-H5-N

Synonyms/Common Names

  • Azabenzene

Known Uses

Solvent, organic synthesis, flavoring ingredient, manufacture of fungicides, pharmaceuticals, dyestuff, explosives, manufacture of vitamins, sulfa drugs, intermediate in manufacture of diquat & paraquat, waterproofing textiles (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14 days (Gavage)  (C10532)  Completed 
    • Mice: B6C3F1
    • Dose: MM: 0, 6.25, 12.5, 25, 50, or 100 mg/kg.
  • 13 weeks (Dosed-Water)  (C55301B)  Completed 
    • Rats: F344/N; Rats: Wistar; Mice: B6C3F1
    • Dose: R&M: 0, 50, 100, 250, 500, OR 1000 PPM.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C55301B)  Report Complete 
    • TR-470 (NIH Number: 003960)  (Peer Review Approval 12/10/1997A )
      Toxicology and Carcinogenesis Studies of Pyridine (CASRN 110-86-1) in F344/N Rats, Wistar Rats, and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Rats: Wistar; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 100, 200, OR 400 PPM MM: 0, 250, 500, OR 1000 PPM FM: 125, 250, OR 500 PPM MWR: 0, 100, 200, OR 400 PPM (50/SEX/GROUP).
  • 2 years (Dosed-Water)  (C55301E)  Report Draft 
    • TR-470 (NIH Number: 003960)  (Peer Review Approval 12/10/1997A )
      Toxicology and Carcinogenesis Studies of Pyridine (CASRN 110-86-1) in F344/N Rats, Wistar Rats, and B6C3F1 Mice (Drinking Water Studies)
    • Rats: Wistar
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 

Special Studies

  • Metabolism  (S0716)  Completed 
    • Citation: Wilke TJ, Jondorf WR, Powis G. Oxidative metabolism of 14C-pyridine by human and rat tissue subcellular fractions. Xenobiotica. 1989 Sep;19(9):1013-22.Pubmed Abstract
    • Male Rats: F344/N; Human (Cell Lines)
  • C. elegans  (S0870)  Completed 
    • C. elegans
    • Dose: feed: (0, 1, 1.6, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100) 6/4/05 repro: (0, 5, 6.3, 7.9 10, 13, 16, 20, 25, 32, 40, 50) 6/2/05 growth: (0, 2.5, 4.0, 6.3, 10, 16, 25, 50, 63, 100, 160, 250) mM 4/17/06.
  • C. elegans  (W10532)  Completed 
    • C. elegans
    • Dose: Growth: 0, 0.1, 0.16, 0.25, 0.40, 0.63, 1.0, 1.6, 2.5, 4.0, 6.3, 10 mMRepro: 0, 0.1, 0.16, 0.25, 0.40, 0.63, 1.0, 1.6, 2.5, 4.0, 6.3, 10 mMFeeding: 0, 0.1, 0.16, 0.28, 0.46, 0.77, 1.3, 2.2, 3.6, 6.0, 10 mM.

Genetic Toxicology

  • Chromosome Aberrations  (A86776)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (148320)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (631306)  Completed 
    • Sister Chromatid Exchange Not a Valid Test 
    • Chromosome Aberrations Not a Valid Test 
  • Drosophila  (372184)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Drosophila  (383713)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (768654)  Completed 
    • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Mouse Lymphoma  (746434)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Negative 
  • Micronucleus  (A16600)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A85799)  Completed 
    • Mice: MICE
    • Male Negative 
    • Female Negative 
  • Salmonella  (364799)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative