National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10534-a

Testing Status of Diethanolamine - 10534-A

 

CASRN: 111-42-2

Formula: C4-H11-N-O2

Synonyms/Common Names

  • DEA
  • 2,2'-Iminobisethanol

Known Uses

In production of textile lubricants. Rubber chemicals intermediate. Emulsifier in agricultural chemicals, cosmetics, and pharmaceuticals. Gas conditioning agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C55174B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 125, 250, 500, 1000, AND 2000 MG/KG; M: 0, 160, 320, 630, 1250, and 2500 mg/kg/ 5D/WK.
  • 2 weeks (Dosed-Water)  (C55174C)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 630, 1250, 2500, 5000, 10000 PPM.
  • 13 weeks (Topical Application)  (C55174B)  Report Complete 
    • TOX-20 (NIH Number: 92-3343)
      Toxicity Studies of Diethanolamine (CASRN 111-42-2) Administered Topically and in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 32, 63, 125, 250, 500 MG/KG; M: 0, 80, 160, 320, 630, OR 1250 MG/KG.
  • 13 weeks (Dosed-Water)  (C55174C)  Report Complete 
    • TOX-20 (NIH Number: 92-3343)
      Toxicity Studies of Diethanolamine (CASRN 111-42-2) Administered Topically and in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR: 0, 320, 630, 1250, 2500, OR 5000 PPM; FR: 0, 160, 320, 630, 1250, OR 2500 PPM; M: 0, 630, 1250, 2500, 5000, OR 10000 PPM.

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C55174D)  Report Complete 
    • TR-478 (NIH Number: 99-3968)  (Peer Review Approval 12/10/1997A )
      Toxicology and Carcinogenesis Studies of Diethanolamine (CASRN 111-42-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: MR: 0, 16, 32, OR 64 MG/KG; FR: 0, 8, 16, OR 32 MG/KG; MICE: 0, 40, 80, OR 160 MG/KG (50/SEX/SPECIES/GROUP).

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (S0145)  Completed 
    • Citation: Mathews JM, Garner CE, Matthews HB. Metabolism, bioaccumulation, and incorporation of diethanolamine into phospholipids. Chem Res Toxicol. 1995 Jul-Aug;8(5):625-33.Pubmed Abstract
    • Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male Mice: B6C3F1
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0813)  Completed 
    • Rats; Mice
  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0814)  Completed 
    • Citation: Project Report #1 Absorption and Disposition of DEA in Rats and Mice after Oral, Dermal and Intravenous Administration.
    • Rats; Mice

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (095123)  Completed 
    • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (375254)  Completed 
    • Mice
    •  Negative 
  • Micronucleus  (A08796)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (310797)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • 14 days Immunotoxicity (Gavage)  (IMM20004)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 100, 300, 400, 500, 600, 700, 800, 900, 1000, 1250, OR 1500 MG/KG.
  • 14 days Immunotoxicity (Gavage)  (IMM20303)  Completed 
    • Female Rats: F344/N
    • Dose: 0, 50 100, OR 200 MG/KG.
  • 14 days Immunotoxicity (Gavage)  (IMM98011)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 100, 300, OR 600 MG/KG (STUDIES 1-11 AND 13); 0, 300, 600, OR 800 MG/KG (STUDY 12).
  • 30 days Neurotoxicology Assessment (Gavage)  (NTA20101)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, 6.67, 20, OR 60 MG/KG.
  • 8 to 15 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0074)  Completed 
    • Female Mice: Swiss
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER96001)  Completed 
    • Citation: Developmental Toxicity Screen for Diethanolamine (CASRN 111-42-2) Administered by Gavage to Sprague-Dawley (CD®) Rats on Gestational Days 6 through 19: Evaluation of Dams and Pups through Postnatal Day 21
    • Female Rats: Sprague Dawley
    • Dose: 0, 50, 125, 200, 250, OR 300 MG/KG/DAY.
  • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP90012)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 50, 200, 500, 800, OR 1200 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.