National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10536-h

Testing Status of Diethylene glycol dimethyl ether - 10536-H

 

CASRN: 111-96-6

Formula: C6-H14-O3

Synonyms/Common Names

  • Ethane, 1,1'-oxybis(2-methoxy-

Known Uses

Medium for grignard & similar reactions; solvent; anhydrous reaction medium for organometallic synthesis

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (586320)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0079A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 3000 MG/KG BD WT.
  • 11 GD (PLUG=GD0) Conventional Teratology (Gavage)  (T0079E)  Completed 
    • Female Mice: Swiss
    • Dose: 537 MG/KG (4.0 MMOL/KG).
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER85061)  Completed 
    • Citation: Teratologic Evaluation of Diethylene Glycol Dimethyl Ether Administered to CD-1 Mice on Gestational Days 6 through 15
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 62.5, 125, 250, 500 MG/KG/DAY.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER86062)  Completed 
    • Citation: Teratologic Evaluation of Diethylene Glycol Dimethyl Ether Administered to New Zealand White Rabbits
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: 0, 25, 50, 100, 175 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.