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Testing Status of Propylene 10538-R

 

CASRN: 115-07-1

Formula: C3-H6

Synonyms/Common Names

  • 1-Propene (9CI)

Known Uses

Production of polypropylene plastics and other chemicals. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C50077)  Completed 
    • TR-272 (NIH Number: 86-2528)  (Peer Review Approval 06/29/1983A )
      Toxicology and Carcinogenesis Studies of Propylene (CASRN 115-07-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 5000, 10000 PPM/50 PER GROUP.

Genetic Toxicology

  • Drosophila  (858707)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (537921)  Completed 
    • Citation: McGregor, D., Brown, A.G., Cattanach, P., Edwards, I., McBride, D., Riach, C., Shepherd, W., and Caspary, W. Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapors. Environ. Molec. Mutagen. Vol. 17 (1991) 122-129
    • Mice
    •  Negative 
  • Salmonella  (779144)  Completed 
    •  Positive