National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10542-a

Testing Status of 2-Aminoanthraquinone - 10542-A

 

CASRN: 117-79-3

Formula: C14-H9-N-O2

Synonyms/Common Names

  • 2-Amino-9,10-anthracenedione

Known Uses

Dye intermediate for dyes used in paints and other pigments

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01876)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01876)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 1, 5 %/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01876)  Report Complete 
    • TR-144 (NIH Number: 78-1399)  (Peer Review Approval 06/29/1978A )
      Bioassay of 2-Aminoanthraquinone for Possible Carcinogenicity (CASRN 117-79-3)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Inadequate Study 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: FR: 0, .2 (AVG), MR: 0, .35, .69 (AVG), M: 0, .5, 1.0 %/50 PER GROUP.

Special Studies

  • C. elegans  (W10542)  Completed 
    • C. elegans
    • Dose: 100, 75, 50 uM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (230007)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (634899)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Positive 
  • Salmonella  (N-9402)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
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