Testing Status of Hexachlorobenzene 10546-R

 

CASRN: 118-74-1

Formula: C6-Cl6

Synonyms/Common Names

  • Amatin

Known Uses

In organic syntheses, intermediate for dyes & hexafluorobenzene, fungicide for wheat, sunflower, manufacture of pentachlorophenol, a wood preservative; peptizing agent in the manufacture of rubber. Manufacture of pentachlorophenol, wood preservative; fungicide, seed treatment (control of wheat bunt); used in the production of aromatic fluorocarbons; organic synthesis; used to impregnate paper. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C10546)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 0.004, 0.015, 0.0625, 0.25, 1, 4, 16, or 64 mg/kg; N=4.
  • 13 weeks (Gavage)  (C98004)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: Females only: 0, .03, .1, .3, 1, 3, 10, or 25 mg/kg; 10/dose.

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0654)  Completed 
    • Citation: Toxicokinetics of Hexachlorobenzene in Female Rats. Amended Final Report II.
    • Female Rats: Sprague Dawley
    • Dose: female rats-gav: 10-5000 ug/kg/day (half life det same doses) 13 weeks at 5 days/week, do repeat dose and single admin. for RD: 6 terminal timepts (11, 22, 33, 44, 55, 66 d) at 3 animals/3 retro-orbital timepts (6, 17, 28d) at 6 animals, for SA: 12 terminal timepts (3, 8hr, 1, 2, 3, 7, 11, 22, 33, 44, 55, 66d) at 3 animals/5 reto-orbital blood timepot (30 min, 1, 12 hr, 5, 9 d)at 6 animals.
  • Toxicokinetic Study (Gavage; Intravenous)  (S0811)  Completed 
    • Citation: Further Investigation of the Toxicokinetics of Hexachlorobenzene in Female Rats. Amended Study Report. June 30, 2003.
    • Female Rats: Sprague Dawley
    • Dose: IV DOSE 1000 AND 100 UG/KG; ORAL DOSE 300 UG/KG.

Genetic Toxicology

  • Salmonella  (880475)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • 6 month Continuous Breeding (Legacy) (Gavage)  (RACB99001)  Completed 
    • Citation: Hexachlorobenzene: Reproductive Assessment by Continuous Breeding When Administered to Sprague-Dawley Rats by Oral Gavage
    • Male and Female Rats: Sprague Dawley
    • Dose: 1-100 OR 1000 MG/KG/DAY.

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T10546)  Assigned 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley