National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10548-y

Testing Status of Methyl salicylate - 10548-Y

 

CASRN: 119-36-8

Formula: C8-H8-O3

Synonyms/Common Names

  • 2-Hydroxybenzoic acid methyl ester (9CI)

Known Uses

Cosmetics and pharmaceuticals, flavor, human & veterinary carminative, UV-absorber, solvent, occurs in many oils incl. Wintergreen, birch, fruit juices (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (005648)  Completed 
    •  Weakly Positive 
  • Salmonella  (537373)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 4 days Immunotoxicity (Topical Application)  (IMM98007)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 1, 2.5, 5, 10, OR 20%.
  • 120 day minimum Continuous Breeding (Legacy) (Gavage)  (RACB82104)  Completed 
    • Citation: Final Report - Methyl Salicylate: Reproduction and Fertility Assessment in CD-1 Mice When Administered By Gavage
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .025, .05, .1 MG/KG; N/A; N/A.
  • 120 day minimum Continuous Breeding (Legacy) (Gavage)  (RACB85061)  Completed 
    • Citation: Final Report - Methyl Salicylate: Fertility Assessment In CD-1 Mice When Administered By Gavage
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .1, .25, .5 MG/KG; N/A; N/A.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.