National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10553-l

Testing Status of Dimethyl terephthalate - 10553-L

 

CASRN: 120-61-6

Formula: C10-H10-O4

Synonyms/Common Names

  • 1,4-Benzenedicarboxylic acid dimethyl ester

Known Uses

Synthesis of polyester fiber

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C50055)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C50055)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 1750, 20000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C50055)  Report Complete 
    • TR-121 (NIH Number: 79-1376)  (Peer Review Approval 12/13/1978A )
      Bioassay of Dimethyl Terephthalate for Possible Carcinogenicity (CASRN 120-61-6)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Equivocal 
      • Female Mice Negative 
    • Dose: 0, 2500, 5000 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (454441)  Completed 
    • Mice
    •  Equivocal 
  • In Vitro Cytogenetics (CA/SCE)  (822999)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (551959)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (954536)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Negative 
  • Micronucleus  (184029)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (003881)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Sister Chromatid Exchanges  (454441)  Completed 
    • Mice
    • Sister Chromatid  Equivocal 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.