National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10554-r

Testing Status of Piperonyl sulfoxide - 10554-R

 

CASRN: 120-62-7

Formula: C18-H28-O3-S

Synonyms/Common Names

  • 5-(2-(Octylsulfinyl)propyl)benzene (9CI)

Known Uses

Synergist in insecticides with pyrethrins

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C02824)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 4600, 21500, M: 0, 50, 2400 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C02824)  Report Complete 
    • TR-124 (NIH Number: 79-1379)  (Peer Review Approval 08/31/1978A )
      Bioassay of Piperonyl Sulfoxide for Possible Carcinogenicity (CASRN 120-62-7)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Negative 
    • Dose: MR: 0, 1500, 3000, FR: 0, 3000, 6000, MM: 0, 350, 700, FM: 0, 295, 754 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (616035)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (552792)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (096915)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (914423)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (974757)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.