National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10556-y

Testing Status of p-Cresidine - 10556-Y

 

CASRN: 120-71-8

Related: M-CRESIDINE (CAS 102-50-1)

Formula: C8-H11-N-O

Synonyms/Common Names

  • 2-Methoxy-5-methylbenzenamine

Known Uses

Chemical intermediate for dyes.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C02982B)  Completed 
    • Mice: MMTV/MYC (Tg.M); Mice: MMTV/NEU (Tg.Nk); Mice: MMTV/RAS (Tg.SH)
    • Dose: 0, 2500, 5000, 10000, OR 20000 PPM.
  • 14-Day (Dosed-Feed)  (C02982)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02982)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 26 & 39 weeks (Dosed-Feed)  (C02982B)  Completed 
    • Mice: MMTV/MYC (Tg.M); Mice: MMTV/NEU (Tg.Nk); Mice: MMTV/RAS (Tg.SH)
    • Dose: 0, 2500, OR 5000 PPM.
  • 2-Year (Dosed-Feed)  (C02982)  Report Complete 
    • TR-142 (NIH Number: 79-1397)  (Peer Review Approval 06/29/1978A )
      Bioassay of p-Cresidine for Possible Carcinogenicity (CASRN 120-71-8)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (459789)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Weakly Positive 
  • Micronucleus  (104686)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (496780)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
  • Salmonella  (N-9378)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
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