National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10560-h

Testing Status of 1,3-Dichloropropene (Telone II) - 10560-H

 

CASRN: 542-75-6

Formula: C3-H4-Cl2

Synonyms/Common Names

  • 1,3-DCP
  • 1,3-Dichloro-1-propene
  • TELONE II

Known Uses

Soil fumigant, nematocide (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13-Week (Gavage)  (C03985)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C03985)  Report Complete 
    • TR-269 (NIH Number: 85-2525)  (Peer Review Approval 07/27/1984A )
      Toxicology and Carcinogenesis Studies of Telone® (Technical-Grade 1,3-Dichloropropane [CASRN 542-75-6] Containing 1.0 Epichlorohydrin as a Stabilizer) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Some Evidence 
      • Male Mice Inadequate Study 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 25, 50, M: 0, 50, 100 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (208737)  Completed 
    • Mice
    •  Positive 
  • In Vitro Cytogenetics (CA/SCE)  (129307)  Completed 
    • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (072802)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Mouse Lymphoma  (725960)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Positive 
  • Micronucleus  (441206)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A15433)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (172972)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Sister Chromatid Exchanges  (208737)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Dosed-Water)  (IMM20201)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 62.5, 125, 250, 500, or 1000 PPM.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.