National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10561-l

Testing Status of 2-Amino-5-nitrothiazole - 10561-L

 

CASRN: 121-66-4

Formula: C3-H3-N3-O2-S

Synonyms/Common Names

  • 5-Nitro-2-thiazolamine

Known Uses

Antiprotozoal drug in animals (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C03065)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 375, 4000, M: 0, 30, 500 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 109 weeks (Dosed-Feed)  (C03065)  Report Complete 
    • TR-053 (NIH Number: 78-1359)  (Peer Review Approval 03/06/1978A )
      Bioassay of 2-Amino-5-Nitrothiazole for Possible Carcinogenicity (CASRN 121-66-4)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 300, 600, M: 0, 50, 100 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (365768)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (G59371)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Mouse Lymphoma  (G77278)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Salmonella  (467333)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
  • Salmonella  (N-9199)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
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