National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10563-v

Testing Status of Malathion - 10563-V

 

CASRN: 121-75-5

Formula: C10-H19-O6-P-S2

Synonyms/Common Names

  • ((Dimethoxyphosphinothioyl)thio)butanedioic acid diethyl ester

Known Uses

Insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00215B)  Completed 
    • Rats: F344/N
  • 13 weeks (Dosed-Feed)  (C00215A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 8000, 32000, M: 0, 4000, 32000 PPM/10 PER GROUP.
  • 13-Week (Dosed-Feed)  (C00215B)  Completed 
    • Rats: F344/N
    • Dose: 0, 1000, 16000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C00215A)  Report Complete 
    • TR-024 (NIH Number: 78-824)  (Peer Review Approval 01/18/1978A )
      Bioassay of Malathion for Possible Carcinogenicity (CASRN 121-75-5)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 6000, 10000 (AVG), M: 0, 8000, 16000 (AVG) PPM/50 PER GROUP.
  • 2-Year (Dosed-Feed)  (C00215B)  Report Complete 
    • TR-192 (NIH Number: 80-1749)  (Peer Review Approval 05/01/1979A )
      Bioassay of Malathion for Possible Carcinogenicity (CASRN 121-75-5)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
    • Dose: 0, 2000, 4000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (973704)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (911111)  Completed 
    • Mice
    •  Equivocal 
  • Salmonella  (218242)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.