Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Malathion 10563-V

 

CASRN: 121-75-5

Formula: C10-H19-O6-P-S2

Synonyms/Common Names

  • ((Dimethoxyphosphinothioyl)thio)butanedioic acid diethyl ester

Known Uses

Insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00215B)  Completed 
    • Rats: F344/N
  • 13 weeks (Dosed-Feed)  (C00215A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 8000, 32000, M: 0, 4000, 32000 PPM/10 PER GROUP.
  • 13-Week (Dosed-Feed)  (C00215B)  Completed 
    • Rats: F344/N
    • Dose: 0, 1000, 16000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C00215A)  Completed 
    • TR-024 (NIH Number: 78-824)  (Peer Review Approval 01/18/1978A )
      Bioassay of Malathion for Possible Carcinogenicity (CASRN 121-75-5)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 6000, 10000 (AVG), M: 0, 8000, 16000 (AVG) PPM/50 PER GROUP.
  • 2-Year (Dosed-Feed)  (C00215B)  Completed 
    • TR-192 (NIH Number: 80-1749)  (Peer Review Approval 05/01/1979A )
      Bioassay of Malathion for Possible Carcinogenicity (CASRN 121-75-5)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
    • Dose: 0, 2000, 4000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (973704)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (911111)  Completed 
    • Mice
    •  Equivocal 
  • Salmonella  (218242)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative