National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10568-p

Testing Status of 1,4-Dioxane - 10568-P

 

CASRN: 123-91-1

Related: 1,3-DIOXANE (CAS 505-22-6)

Formula: C4-H8-O2

Synonyms/Common Names

  • p-Dioxane

Known Uses

Industrial and lab solvent used in lacquers, paints, dyes, resins, oils and waxes. In biological and chemical laboratories, dioxane is employed as a solvent for tissue processing, liquid scintillation counting, and photochemical reactions.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C03689B)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C03689B)  Report Complete 
    • TR-080 (NIH Number: 78-1330)  (Peer Review Approval 03/07/1978A )
      Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0,0.5,1.0 %/70R - 100M PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (950869)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (058941)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (120802)  Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    • Mice
    •  Negative 
  • Micronucleus  (787385)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Micronucleus  (906732)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (123659)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (709799)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (882515)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.