National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10575-k

Testing Status of Butylated hydroxytoluene - 10575-K

 

CASRN: 128-37-0

Formula: C15-H24-O

Synonyms/Common Names

  • BHT
  • 2,6-Bis(1,1-dimethylethyl)-4-methylphenol

Known Uses

Antioxidant for petroleum and food products; animal feed; food packaging. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C03598)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,6200,50000, M: 0,3100,50000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C03598)  Report Complete 
    • TR-150 (NIH Number: 79-1706)  (Peer Review Approval 12/13/1978A )
      Bioassay of Butylated Hydroxytoluene (BHT) for Possible Carcinogenicity (CASRN 128-37-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0,3000,6000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (549686)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (441614)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Micronucleus  (A82929)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (377283)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.