National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10577-t

Testing Status of Pyrene - 10577-T

 

CASRN: 129-00-0

Formula: C16-H10

Synonyms/Common Names

  • Benzo(def)phenanthrene

Known Uses

Biochemical research, occurs in coal tar, foods, roasted coffee, vegetable oils (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Chromosome Aberrations  (A72952)  Completed 
    • Citation: Luke, C.A., Tice, R.R., Miller, V.M., Ormiston, B.G., Wilton, A.C., and Shelby, M.D. Comparative analysis of the induction of chromosome aberrations in the bone marrow cells of B6C3F1 mice. In Evaluation of Short-term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays, Cambridge Univ. Press, Cambridge, UK Vol. (1988) 1,123-1,131
    • Citation: Tice, R.R., Luke, C.A., Miller, V.M., Ormiston, B.G., Wilton, A.C., and Shelby, M.D. Comparative analysis of the induction of sister-chromatid exchanges in bone marrow cells of B6C3F1 mice. In Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays, Cambridge Univ. Press, Cambridge, UK 1,254-1,259
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (587427)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (094614)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Mouse Lymphoma  (398036)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Salmonella  (023116)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
  • Salmonella  (N-9150)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
  • Sister Chromatid Exchanges  (A72952)  Completed 
    • Citation: Luke, C.A., Tice, R.R., Miller, V.M., Ormiston, B.G., Wilton, A.C., and Shelby, M.D. Comparative analysis of the induction of chromosome aberrations in the bone marrow cells of B6C3F1 mice. In Evaluation of Short-term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays, Cambridge Univ. Press, Cambridge, UK Vol. (1988) 1,123-1,131
    • Citation: Tice, R.R., Luke, C.A., Miller, V.M., Ormiston, B.G., Wilton, A.C., and Shelby, M.D. Comparative analysis of the induction of sister-chromatid exchanges in bone marrow cells of B6C3F1 mice. In Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays, Cambridge Univ. Press, Cambridge, UK 1,254-1,259
    • Mice
    • Sister Chromatid  Negative 

Organ Systems Toxicity

  • Dominant Lethal (Female)  (DLF063)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Braden, P. W. Tests for induction of presumed dominant lethal effects in female mice, In: Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays (J. Ashby, F.J. deSerres, M.D. Shelby, B.H. Margolin, M. Ishidate, and G.C. Becking, Eds.). Cambridge Univ. Press, Cambridge, UK, 1988, pp. 2.189-2.193.
    • Female Mice: C3H X C57BL
    • Mice Female Negative 
  • Dominant Lethal (Female)  (DLF064)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Braden, P. W. Tests for induction of presumed dominant lethal effects in female mice, In: Evaluation of Short-Term Tests for Carcinogens: Report of the IPCS Collaborative Study on In Vivo Assays (J. Ashby, F.J. deSerres, M.D. Shelby, B.H. Margolin, M. Ishidate, and G.C. Becking, Eds.). Cambridge Univ. Press, Cambridge, UK, 1988, pp. 2.189-2.193.
    • Female Mice: T-Stock
    • Mice Female Negative 
  • 28 days Immunotoxicity (Gavage)  (I10577)  Report in Preparation 
    • Female Mice: B6C3F1
    • Dose: 0, 3.1, 6.3, 12.5, 25, 50, 100, or 200 mg/kg.
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