National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10578-x

Testing Status of Diallyl phthalate - 10578-X

 

CASRN: 131-17-9

Formula: C14-H14-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, di-2-propenyl ester
  • Diallylphthalate

Known Uses

Forms laminates with various fillers (e.g. Glass cloth). Electrical insulation. Dye carrier. Primary plasticizer.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C50657A)  Completed 
    • Mice: B6C3F1
  • 14-Day (Gavage)  (C50657B)  Completed 
    • Rats: F344/N
  • 13 weeks (Gavage)  (C50657A)  Completed 
    • Mice: B6C3F1
    • Dose: 0,25,400 MG/KG/10 PER GROUP.
  • 13-Week (Gavage)  (C50657B)  Completed 
    • Rats: F344/N

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C50657A)  Report Complete 
    • TR-242 (NIH Number: 83-1798)  (Peer Review Approval 06/16/1982A )
      Carcinogenesis Bioassay of Diallyl Phthalate (CASRN 131-17-9) in B6C3F1 Mice (Gavage Study)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Equivocal 
      • Female Mice Equivocal 
    • Dose: 0,150,300 MG/KG/50 PER GROUP.
  • 2-Year (Gavage)  (C50657B)  Report Complete 
    • TR-284 (NIH Number: 85-2540)  (Peer Review Approval 03/23/1984A )
      Toxicology and Carcinogenesis Studies of Diallylphthalate (CASRN 131-17-9) in F344/N Rats (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0228)  Completed 
    • Citation: Eigenberg DA, Carter DE, Schram KH, Sipes IG. Examination of the differential hepatotoxicity of diallyl phthalate in rats and mice. Toxicol Appl Pharmacol. 1986 Oct;86(1):12-21.Pubmed Abstract
    • Rats; Mice; Rats; Mice

Genetic Toxicology

  • Chromosome Aberrations  (993263)  Completed 
    • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
    • Mice
    •  Positive 
  • In Vitro Cytogenetics (CA/SCE)  (154517)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (574773)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (871217)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Positive 
  • Micronucleus  (730162)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A49968)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (079950)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Salmonella  (258261)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Sister Chromatid Exchanges  (993263)  Completed 
    • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
    • Mice
    • Sister Chromatid  Positive 
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