National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10579-c

Testing Status of 3-Amino-9-ethylcarbazole HCl - 10579-C

 

CASRN: 6109-97-3

Formula: C14-H14-N2.Cl-H

Synonyms/Common Names

  • 9H-Carbazol-3-amine, 9-ethyl-, monohydrochloride (1:1)

Known Uses

Pigments. An aromatic amine dye intermediate that has been used industrially in the manufacture of C.I. Pigment Violet 23 and C.I. Direct Blue 108.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03043)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03043)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 40, 1440 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03043)  Report Complete 
    • TR-093 (NIH Number: 78-1337)  (Peer Review Approval 06/29/1978A )
      Bioassay of 3-Amino-9-ethylcarbazole Hydrochloride for Possible Carcinogenicity (CASRN 132-32-1)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 800, 2000, M: 0, 800, 1200 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (688225)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (918212)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
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