National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10580-y

Testing Status of Dibenzofuran - 10580-Y

 

CASRN: 132-64-9

Formula: C12-H8-O

Synonyms/Common Names

  • (1,1'-Biphenyl)-2,2'-diyl oxide
  • 2,2'-Biphenylene oxide
  • Diphenylene oxide

Known Uses

Naturally occurring in coal tar. Component of heat-transfer oils. Used in polymer production and in dyeing and printing of textiles. Released into air from the incomplete combustion of coal & oil products. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Mechanisms (Gavage)  (S0464)  Completed 
    • Citation: Birnbaum LS, Harris MW, Crawford DD, Morrissey RE. Teratogenic effects of polychlorinated dibenzofurans in combination in C57BL/6N mice. Toxicol Appl Pharmacol. 1987 Nov;91(2):246-55.Pubmed Abstract
    • Mice: C57BL/6

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (578267)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (618477)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
    •  Negative 
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