Testing Status of Penicillin VK 10581-D

 

CASRN: 132-98-9

Formula: C16-H18-N2-O5-S.K

Synonyms/Common Names

  • (2S-(2alpha,5alpha,6beta))-3,3-dimethyl-7-oxo-6((phenoxyacetyl)amino)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid monopotassium salt (9CI)

Known Uses

Antibiotic

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C56100)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56100)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 180, 3000 M: 0, 250, 3000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C56100)  Report Complete 
    • TR-336 (NIH Number: 88-2592)  (Peer Review Approval 07/14/1987A )
      Toxicology and Carcinogenesis Studies of Penicillin VK (CASRN 132-98-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 500, 1000 MG/KG/ 50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (130786)  Completed 
    • Sister Chromatid Exchange Not Tested 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (391874)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Not a Valid Test 
  • Mouse Lymphoma  (698417)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Mouse Lymphoma  (954196)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Salmonella  (688328)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative