National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10582-g

Testing Status of o-Anisidine hydrochloride - 10582-G

 

CASRN: 134-29-2

Related: O-ANISIDINE (90-04-0)

Formula: C7-H9-N-O.Cl-H

Synonyms/Common Names

  • 2-Methoxybenzenamine hydrochloride

Known Uses

Manufacture of azo dyes; formerly listed as possible ingredient in permanent oxidation hair dyes (no longer used in the US). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03747)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03747)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03747)  Report Complete 
    • TR-089 (NIH Number: 78-1339)  (Peer Review Approval 04/26/1978A )
      Bioassay of o-Anisidine Hydrochloride for Possible Carcinogenicity (CASRN 134-29-2)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 

Genetic Toxicology

  • Micronucleus  (563139)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (N-9366)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
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