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Testing Status of Ephedrine sulfate 10584-P

 

CASRN: 134-72-5

Formula: C10-H15-N-O.1/2H2-O4-S

Synonyms/Common Names

  • 1-alpha-(1-(Methylamino)ethyl)benzyl alcohol sulfate

Known Uses

Medicine (bronchodilator). Veterinary medicine as a mydriatic and sympathomimetic in allergic reactions. CNS stimulant.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C55652)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55652)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 125, 2000, M: 0, 310, 5000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C55652)  Completed 
    • TR-307 (NIH Number: 86-2563)  (Peer Review Approval 08/14/1985A )
      Toxicology and Carcinogenesis Studies of Ephedrine Sulfate (CASRN 134-72-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 125, 250 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (627991)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Not a Valid Test 
  • In Vitro Cytogenetics (CA/SCE)  (932450)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (873748)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (232351)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative