National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10586-x

Testing Status of N-Phenyl-2-naphthylamine - 10586-X

 

CASRN: 135-88-6

Formula: C16-H13-N

Synonyms/Common Names

  • N-Phenyl-2-naphthalenamine (9CI)

Known Uses

Rubber antioxidant. Lubricant. Catalyst. In dyes, surgical plasters. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02915)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02915)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 2500, 45000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 108 weeks (Dosed-Feed)  (C02915)  Report Complete 
    • TR-333 (NIH Number: 88-2589)  (Peer Review Approval 03/04/1987A )
      Toxicology and Carcinogenesis Studies of N-Phenyl-2-Naphthylamine (CASRN 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: 0, 2500, 5000 PPM/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0216)  Completed 
    • Citation: Metabolism of N-phenyl-2-naphthylamine (PNA) after Feeding to Fischer 344 Rats. October 15, 1986
    • Male Rats: F344/N
    • Dose: 0.465 & 0.216% X 8 DAYS.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (796411)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (945201)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Salmonella  (585564)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
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