National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10588-f

Testing Status of 4-Hexylresorcinol - 10588-F

 

CASRN: 136-77-6

Formula: C12-H18-O2

Synonyms/Common Names

  • 4-Hexyl-1,3-benzenediol (9CI)

Known Uses

Anthelmintic, topical antiseptic.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55787)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55787)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 62.5, 1000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55787)  Report Complete 
    • TR-330 (NIH Number: 88-2586)  (Peer Review Approval 03/04/1987A )
      Toxicology and Carcinogenesis Studies of 4-Hexylresorcinol (CASRN 136-77-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 62.5, 125 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (813308)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (356349)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Micronucleus  (A25951)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A27137)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (267489)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (948583)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
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